KDR

KDR
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1VR2, 1Y6A, 1Y6B, 1YWN, 2M59, 2MET, 2MEU, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 2XIR, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ, 3S35, 3S36, 3S37, 3U6J, 3VHE, 3VHK, 3VID, 3VNT, 3VO3, 3WZD, 3WZE, 4AG8, 4AGC, 4AGD, 4ASD, 4ASE, 5EW3
Identifikatori
Aliasi	KDR
Vanjski ID-jevi	OMIM: 191306 MGI: 96683 HomoloGene: 55639 GeneCards: KDR
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q12 Početak 55,078,481 bp[1] Kraj 55,125,595 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5 C3.3|5 40.23 cM Početak 76,093,487 bp[2] Kraj 76,139,118 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • Hsp90 protein binding • nucleotide binding • protein kinase activity • growth factor binding • vascular endothelial growth factor binding • kinase activity • integrin binding • GO:0001948, GO:0016582 vezivanje za proteine • ATP binding • transmembrane receptor protein tyrosine kinase activity • vascular endothelial growth factor-activated receptor activity • protein tyrosine kinase activity • vezivanje identičnih proteina • Receptorska tirozin-kinaza • transmembrane signaling receptor activity • cadherin binding Ćelijska komponenta • citoplazma • integral component of membrane • Golđijev aparat • membrana • integral component of plasma membrane • extracellular region • međućelijske veze • early endosome • Lipidni splav • sorting endosome • GO:0016023 citoplazmatska vezikula • jedro • endozom • ćelijska membrana • Endoplazmatski retikulum • receptor complex Biološki proces • negative regulation of endothelial cell apoptotic process • Ćelijska diferencijacija • positive regulation of protein phosphorylation • positive regulation of mitochondrial fission • positive regulation of endothelial cell proliferation • Fosforilacija • extracellular matrix organization • negative regulation of apoptotic process • positive regulation of nitric-oxide synthase biosynthetic process • cell migration involved in sprouting angiogenesis • positive regulation of angiogenesis • Vaskulogeneza • positive regulation of endothelial cell migration • multicellular organism development • protein phosphorylation • positive regulation of macroautophagy • positive regulation of mitochondrial depolarization • positive regulation of vasculogenesis • embryonic hemopoiesis • endothelium development • regulation of cell shape • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • positive regulation of focal adhesion assembly • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • GO:0022415 viral process • calcium-mediated signaling using intracellular calcium source • positive regulation of MAPK cascade • positive regulation of positive chemotaxis • transmembrane receptor protein tyrosine kinase signaling pathway • vascular endothelial growth factor receptor signaling pathway • positive regulation of cell population proliferation • Angiogeneza • positive regulation of cell migration • protein kinase B signaling • ERK1 and ERK2 cascade • negative regulation of gene expression • positive regulation of blood vessel endothelial cell migration • cellular response to hydrogen sulfide • positive regulation of cell migration involved in sprouting angiogenesis • negative regulation of signal transduction • sprouting angiogenesis • Ćelijska migracija • endothelial cell differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3791	16542
Ensembl	ENSG00000128052	ENSMUSG00000062960
UniProt	P35968	P35918 Q8VCD0
RefSeq (mRNK)	NM_002253	NM_010612 NM_001363216
RefSeq (bjelančevina)	NP_002244	NP_034742 NP_001350145
Lokacija (UCSC)	Chr 4: 55.08 – 55.13 Mb	Chr 5: 76.09 – 76.14 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor domena kinazne insercije (KDR, tip IV receptora tirozin-kinaza), znan i kao receptor 2 vaskularnog endotelnog faktora rasta (VEGFR-2) jest VEGF-receptor koji je kod ljudi kodiran genom KDR sa hromosoma 4. Označava se i kao CD309 (klaster diferencijacije 309) i kao Flk1 (eng. Fetal Liver Kinase 1 = fetusna jetrena kinaza).

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000128052 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000062960 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.